Royal life seems so glamorous. But the truth is that from inbreeding to fatty royal diets, the men and women who sat on thrones in the past had a lot of health issues.

Whether it’s a genetic defect or a condition brought on by “royal” behavior, these 15 members of ruling families did not lead entirely comfortable lives. In fact, many of them died young due to their afflictions.

Check out these 15 royal maladies: